“What are We Missing?” Usability’s Indexical Ground

Assessing drug-likeness--what are we missing?

The concept of drug-likeness helps to optimise pharmacokinetic and pharmaceutical properties, for example, solubility, chemical stability, bioavailability and distribution profile. A number of molecular descriptors have emerged as reasonably informative and predictive, for example, the Rule-of-Five. Here, we review some current approaches, then discuss their major shortcoming, namely the static...

Newborn hearing screening: what are we missing?

The objectives of the study were to demonstrate hearing status in newborns at first screening by Transient Evoked Otoacoustic Emissions and to find out the relationship between abnormal hearing screening and known risk factors. This study was conducted in the department of neonatology of Bangabandhu Sheikh Mujib Medical University in collaboration with department of otolaryngology and departmen...

Efficient isolation of campylobacters from stools: what are we missing?

The past three decades have witnessed the rise of campylobacter enteritis in humans from virtual obscurity to notoriety, with present isolation rates superseding those of other enteric pathogens such as Salmonella spp. and Shigella spp. in most developed countries. Unlike the salmonellae and other enteric pathogens, most (∼ 99%) clinical reports concerning campylobacter are sporadic, and campyl...

Tuberculosis and TNFα antagonists--what are we missing?

Evidence-based health care for children: what are we missing?

With the enactment of comprehensive health reform, reimbursement for a variety of health care services will likely depend on evidence to support that provision. Understanding what constitutes "evidence" will have a profound effect on the range of clinical care provided. A too-narrow definition may have a considerable impact on pediatric care in particular: much of current child health care requ...